Adverse Event FLOVENT HFA88 mcg Twice Daily
(n=203)%
FLOVENT HFA 220 mcg Twice Daily
(n = 204)%
FLOVENT HFA 440 mcg Twice Daily
(n = 202)%
Placebo
(n = 203)%
Ear, nose, and throat
  Upper respiratory tract infection 18 16 16 14
  Throat irritation 8 8 10 5
  Upper respiratory inflammation 2 5 5 1
  Sinusitis/sinus infection 6 7 4 3
  Hoarseness/dysphonia 2 3 6 < 1
Gastrointestinal
  Candidiasis mouth/throat and non-site specific 4 2 5 < 1
Lower respiratory
  Cough 4 6 4 5
  Bronchitis 2 2 6 5
Neurological
  Headache 11 7 5 6

Number

Uncertainty notation

Number of such entries in SI database, post-1600

Number of such entries in Witham database, post-1600

1

Completely unknown (“?”)

48

7

2

“Few” or “Few?”

3

2

3

“Some” or “Some?”

4

3

4

“Several” or “Several?”

8

0

5

“Many” or “Many?”

21

1

6

“Hundreds”

1

0

7

Approximate (“~x”)

9

2

8

Uncertain (“x?”)

57

6

9

Below a certain threshold (“<x”)

1

0

10

Above a certain threshold (“>x”)

13

3

11

Above an uncertain threshold (“>x?”)

5

1

12

Two options(“x or y”)

0

2

13

Two options, with one uncertain(“x or y?”)

0

2

14

Range with certain endpoints (“x-y”)

0

42

15

Range with one uncertain endpoint (“x - >y” or“> x – y”)

0

9

В 

Total

170

80

hr Sales Manager salaries - 1 salaries reported$46,795/
Adverse Event FLOVENT HFA88 mcg Twice Daily
(n=203)%
FLOVENT HFA 220 mcg Twice Daily
(n = 204)%
FLOVENT HFA 440 mcg Twice Daily
(n = 202)%
Placebo
(n = 203)%
Ear, nose, and throat
  Upper respiratory tract infection 18 16 16 14
  Throat irritation 8 8 10 5
  Upper respiratory inflammation 2 5 5 1
  Sinusitis/sinus infection 6 7 4 3
  Hoarseness/dysphonia 2 3 6 < 1
Gastrointestinal
  Candidiasis mouth/throat and non-site specific 4 2 5 < 1
Lower respiratory
  Cough 4 6 4 5
  Bronchitis 2 2 6 5
Neurological
  Headache 11 7 5 6
1
Adverse Event FLOVENT HFA88 mcg Twice Daily
(n=203)%
FLOVENT HFA 220 mcg Twice Daily
(n = 204)%
FLOVENT HFA 440 mcg Twice Daily
(n = 202)%
Placebo
(n = 203)%
Ear, nose, and throat
  Upper respiratory tract infection 18 16 16 14
  Throat irritation 8 8 10 5
  Upper respiratory inflammation 2 5 5 1
  Sinusitis/sinus infection 6 7 4 3
  Hoarseness/dysphonia 2 3 6 < 1
Gastrointestinal
  Candidiasis mouth/throat and non-site specific 4 2 5 < 1
Lower respiratory
  Cough 4 6 4 5
  Bronchitis 2 2 6 5
Neurological
  Headache 11 7 5 6
2


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